Estrogen and HER‐2 Receptor Discordance Between Primary Breast Cancer and Metastasis
نویسندگان
چکیده
منابع مشابه
Receptor status (ER, PgR and HER2) discordance between primary tumor and locoregional recurrence in breast cancer.
We report on three cases in which the HER2 status of a locoregional recurrence differed from that in the primary breast cancer. In one of these cases, estrogen receptor (ER) status also changed from primary to locoregional recurrence. All patients received neoadjuvant chemotherapy. Changes in HER2 and ER status between primary and metastatic breast cancer is a growing feature of the literature;...
متن کاملHormonal Receptor and HER2 Status Primary Breast Tumors and Paired Nodal Metastases: Discordance and Prognosis
Breast cancer is one of the most common causes of cancer-related deaths worldwide. The prediction of clinical outcome and the selection of patients for adjuvant therapy are currently based on prognostic factors [age, hormone receptor status, human epidermal growth factor receptor 2 (HER2) expression, tumor size, and lymph node involvement] according to international guidelines (Cinieri et al., ...
متن کاملRelation between Estrogen and Progesterone Receptor Status with p53, Ki67 and Her-2 Markers in Patients with Breast Cancer
Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...
متن کاملDiscordance between core needle biopsy (CNB) and excisional biopsy (EB) for estrogen receptor (ER), progesterone receptor (PgR) and HER2 status in early breast cancer (EBC).
BACKGROUND Analysis of estrogen receptor (ER), progesterone receptor (PgR) and HER2 status in early breast cancer (EBC) is increasingly being conducted in core needle biopsies (CNBs) taken at diagnosis but the concordance with the excisional biopsy (EB) is poorly documented. PATIENTS AND METHODS Patients with EBC presenting to The Royal Marsden Hospital from June 2005 to September 2007 who ha...
متن کاملComparative study of receptor discordance between primary and corresponding metastatic lesions in breast cancer.
PURPOSE It is well-known that tumor phenotype may change during the progression of breast cancer (BC). The purpose in this study was to compare the discordance in estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) between primary and recurrent/metastatic lesions (RML) and also to evaluate the prognostic significance of change in tumor phenoty...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Oncologist
سال: 2010
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2010-0059